84-4387-39　［取扱停止］GREM2 (Gremlin-2, Cysteine Knot Superfamily 1, BMP Antagonist 2, DAN Domain Family Member 3, Protein Related to DAN and Cerberus, GREM2, CKTSF1B2, DAND3, PRDC) 100ul　360357

特徴

• The gremlin protein family contains antagonists of bone morphogenetic protein (BMP) signaling that are expressed in the neural crest.
• All family members are secreted proteins that act as BMP antagonists in embryonic explants and are expressed in the proximal airway epithelium of the lung during embryonic development.
• Gremlin-1 is required for early limb outgrowth and patterning in the FGF4-SHH feedback loop, while gremlin-2 binds and blocks the activity of BMP-2 and BMP-4.
• The dorsaling factor gremlin belongs to a novel gene family that includes the head-inducing factor Cerberus and the tumor suppressor DAN.
• Additionally, secreted gremlin relays the sonic hedgehog signal from the polarizing region to the apical ectodermal ridge.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.