84-4386-82　［取扱停止］GNG5 (Guanine Nucleotide-binding Protein G(I)/G(S)/G(O) Subunit gamma-5, GNG5, GNGT5) 100ul　360325

特徴

• Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors.
• Each of a very broad range of receptors specifically detects an extracellular stimulus(a photon, pheromone, odorant, hormone or neuro transmitter) while the effectors(e.g., adenylcyclase),which act to generate one or more intracellular messengers, are less numerous.
• In mammals, G protein alpha, beta and gamma polypeptides are encoded by at least 16, 4 and 7 genes, respectively.
• Most interest in G proteins has been focused on their alpha subunits, since these proteins bind and hydrolyze GTP and most obvously regulate the activity of the best studied effectors.
• Evidence, however, has established an important regulatory role for the beta gamma subunits.
• It is becoming increasingly clear that different G protein complexes expressed in diffeent tissues carry structurally distinct members of the gamma as well as the alpha and beta subunits and that preferential associations between members of subunit families increase G protein functional diversity.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.