GM2-AP (GM2 ganglioside activator), also known as GM2A or SAP-3 (shingolipid activator protein 3), is a 193aa protein that localizes to the lysosome.
Existing as a small glycolipid transport protein, GM2-AP acts as a ganglioside-specific cofactor that, together with beta-hexosaminidase A (HEXA), stimulates the breakdown of glycolipid GA2 and ganglioside GM2 and is important for the degradation of proteins containing terminal N-acetyl hexosamines.
Mutations in the gene encoding GM2-AP are the cause of GM2-gangliosidosis type AB (GM2GAB), which is also known as Tay-Sachs disease AB variant, and is an autosomal recessive disease that is characterized by ganglioside GM2 accumulation in the presence of both hexosaminidase A and B.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human GM2A.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human GM2A.
