Glucagon, a pancreatic hormone, functions as an antagonist to insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels.
GLP-1 functions as a transmitter in the central nervous system, inhibiting feeding and drinking behavior.
Both Glucagon and GLP-1 function through their specific binding to the Glucagon Receptor or GLP-1R, respectively.
The Glucagon Receptor is expressed in liver, kidney and adipose tissue.
The GLP-1R expression primarily localizes to areas of the hypothalamus involved in feeding behavior.
Both receptors and their ligands serve as potential targets for the therapeutic treatment of diabetes.
Glucagon-like peptide 2 receptor, also designated GLP-2 receptor or glp-2r, acts as a receptor for Glucagon-like peptide 2 (GLP-2).
GLP-2 is a nutrient-responsive hormone that has various functions in the gastrointestinal tract.
The activity of GLP-2R, which is a multi-pass membrane protein, is mediated by G-proteins which activate adenylyl cyclase.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human GLP2R. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to human GLP2R.
