Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus.
Members of the Ets gene family exhibit varied patterns of tissue expression and share a highly conserved C-terminal domain which contains a sequence related to the SV40 large T antigen nuclear localization sequence.
This conserved carboxy domain is essential for Ets-1 binding to DNA and is likely to be responsible for the DNA binding activity of all members of the Ets gene family.
TEL2, also known as ETV7 (ets variant gene 7), TREF or TELB, is a 341aa nuclear protein that contains one PNT domain and one Ets DNA-binding domain.
Expressed in hematopoietic tissue, TEL2 belongs to the Ets family and functions as a transcriptional repressor that binds to the DNA sequence 5'-CCGGAAGT-3'.
Defects in the gene encoding TEL2 are associated with B-cell malignancies, suggesting an important role for TEL2 in carcinogenesis.
Seven isoforms (designated A-G) of TEL2 exist due to alternative splicing events.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human ETV7.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human ETV7.
