84-4383-69　［取扱停止］DOCK11 (Dedicator of Cytokinesis Protein 11, Activated Cdc42-Associated Guanine Nucleotide Exchange Factor, ACG, Zizimin-2, DOCK11, ZIZ2) 100ul　360123

特徴

• Small GTPases of the Rho family, Rho, Rac, and Cdc42, are critical regulators of the actin cytoskeleton and many other cellular processes.
• Rho GTPases are activated by Dbl-homology (DH)-domain-containing guanine nucleotide exchange factors (GEFs).
• DOCK 11 (dedicator of cytokinesis 11), also known as ACG or ZIZ2 (zizimin2), is a 2073aa protein belonging to the DOCK family of cytokinesis-regulating proteins that is mainly expressed in peripheral blood leukocytes.
• DOCK 11 functions as a GEF that binds and activates Cdc42 by exchanging bound GDP for free GTP.
• Cdc42 mediates cell polarity, gene expression, cell cycle progression and cell–cell contacts.
• Similar to other DOCK family members, DOCK 11 contains a PH domain and two internal DOCK homology regions designated DHR1 and DHR2.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.