84-4383-41　［取扱停止］DLK1 (Protein delta Homolog 1, DLK-1, pG2, DLK) 100ul　360109

特徴

• The human DLK gene maps to human chromosome 14q32 and encodes a 383aa protein.
• DLK, also designated preadipocyte factor 1 (pref-1), ZOG, pG2 or FA1, is a transmembrane protein with six tandem EGF-like repeats in the putative extracellular domain, which is characteristic of the EGF-like protein family.
• DLK shares homology with invertebrate homeotic proteins, including Delta and Notch, which are proteins that mediate normal neural differentiation in Drosophila.
• In mammalian preadipocytes, multiple discrete forms of DLK protein are present due to N-linked glycosylation.
• DLK is expressed in tumors with neuroendocrine features, such as neuroblastoma and pheochromocytoma cell lines.
• Normal tissue expression is restricted to the adrenal gland and placenta.
• Protein-protein interaction between DLK proteins belonging to the same or to different cells, or the interaction between soluble and membrane DLK variants, may be important in regulation of DLK function.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.