84-4383-13　［取扱停止］DDX3 (ATP-Dependent RNA Helicase DDX3X, DEAD Box Protein 3, X-chromosomal, DEAD Box, X isoform, Helicase-like Protein 2, HLP2, DDX3X, DBX) 100ul　360094

特徴

• DDX3 contains all of the motifs of the DEAD box family of RNA helicases, including the Asp/Glu/Ala/Asp sequence that gives the protein family its name and distinguishes it from other RNA helicases.
• DDX3 is localized to the X chromosome and has a highly conserved functional homolog (DBY) on the Y chromosome.
• DDX3 is thought to be involved in RNA splicing, RNA transport, and translation initiation.
• It is also involved in cell growth control and is deregulated in hepatitis virus associated hepatocellular carcinoma.
• Recent experiments suppressing DDX3 expression blocked HIV1 RNA export from the nucleus, suggesting that DDX3 functions as a shuttling protein that transports the HIV1 protein Rev and its cofactor CRM1 from the nucleus to the cytoplasm.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.