84-4382-55　［取扱停止］CX3CL1 (Fractalkine, C-X3-C Motif Chemokine 1, CX3C Membrane-anchored Chemokine, Neurotactin, Small-inducible Cytokine D1, FKN, NTT, SCYD1) 50ul　360060

特徴

• Chemokines are members of a superfamily of inducible, secreted, proinflammatory cytokines.
• Members of the chemokine family exhibit 20-50% homology in their predicted amino acid sequences and are divided into four subfamilies.
• In the subfamily designated C-C or B, the first two cysteines are adjacent.
• In the C-X-C or a subfamily, the first two of four cysteine residues are separated by a single amino acid.
• C subfamily members, also designated gamma chemokines, lack the first and third cysteine residues of the conserved motif.
• Chemokines in these three subfamilies are small, secreted proteins with molecular weights ranging from 7-15kD.
• Fractalkine, also designated neurotactin, is the first characterized member of a fourth chemokine subfamily.
• Fractalkine contains a novel C-X3-C motif in which the first two cysteines are separated by three amino acid residues.
• Fractalkine mRNA has been detected in brain and heart and is upregulated in microglia and endothelial cells by inflammatory signals.
• The protein can exist both as a membranebound form and as a chemotactic soluble form.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.