84-4382-40　［取扱停止］CTSA (Lysosomal Protective Protein, Carboxypeptidase C, Carboxypeptidase L, Cathepsin A, Protective Protein Cathepsin A, PPCA, Protective Protein for beta-galactosidase, PPGB) 100ul　360052

特徴

• The cathepsin family of proteolytic enzymes include several diverse classes of proteases.
• Cathepsins B, L, H, K, S and O comprise the cysteine protease class.
• Cathepsins D and E comprise the aspartyle protease class.
• The serine protease class includes cathepsin G.
• Cathepsins function in cellular metabolism and participate in peptide biosynthesis and protein degradation.
• Cathepsin A, a serine carboxypeptidase, exists in a high molecular weight lysosomal complex with b-galactosidase (b-gal) and a-neuraminidase (Neu1).
• Cathepsin A functions to protect b-gal and Neu1 from intralysosomal proteolysis.
• Deficiencies in cathepsin A lead to deficiencies in b-gal and Neu1.
• The gene encoding human cathepsin A maps to chromosome 20q13.12.
• Mutations in this gene cause glactosialidosis, a lysosomal storage disorder resulting from the b-gal and Neu1 deficiencies.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.