The human IL-3, IL-5 and GM-CSF receptors are each composed of both unique a subunits and a common B subunit.
The a subunits are low affinity ligand binding proteins while the B subunits do not themselves bind ligand, but are required for high affinity binding by the a subunits.
In contrast, the mouse IL-3 receptor has two distinct B subunits, one that functions only in IL-3 mediated cell signaling and a second that is shared with IL-5 and GM-CSF.
The murine B-subunits are 91% homologous at the aa level but only 56% homologous to the human B subunit.
Although neither the murine nor the human B subunit contains tyrosine kinase domains, both activate tyrosine phosphorylation mediated signaling pathways.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes human CSF2RA. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human CSFR2RA.
