Members of the M14 metallocarboxypeptidase protein family serve many diverse functions and are divided into three subfamilies based on structure, function and amino acid sequence similarity.
Belonging to the N/E subfamily, CPXM2 (Inactive carboxypeptidase-like protein X2) is a 756aa protein that contains a F5/8 type C domain and is secreted.
Most members of the N/E subfamily contain several domains, including an active carboxypeptidase domain and signal peptide and are thought to function mostly in mediating protein-protein interactions and/or protein-membrane interactions, thereby targeting the protein to specific locations within the secretory pathway.
CPXM2 is a unique member of this subfamily in that it does not appear to exhibit any enzymatic activity due to lack of several active-site residues that are present in the catalytic domain of other members of the N/E subfamily.
Expression of the closely related protein CPXM is regulated during osteoclastogenesis, suggesting that CPXM may play a role in osteoclast differentiation.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes human CPXM2. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human CPXM2.
