The Collagen Type IX protein (also known as Collagen alpha1 Type IX) is encoded by the COL9A1 gene which possesses two promoter regions and codes for both a long chain Collagen Type IX protein expressed in the cartilage, and a shorter Collagen Type IX protein expressed in the cornea and vitreous.
Collagen Type IX forms a heterotrimer with Collagen alpha2 Type IX and Collagen alpha3 Type IX.
When it is expressed in hyaline cartilage, Collagen Type IX posseses a large N-terminal globular domain (NC4).
The COL9A1 gene is also expressed in the human inner ear, and disruption of this gene in mice results in hearing loss, indicating the role of Collagen Type IX in hearing.
Mutations in the COL9A1 gene are associated with multiple epiphyseal dysplasia (MED), a chondrodysplasia, in humans.
Collagen Type IX is often co-localized with Collagen Type II, and may play a role in the interaction of fibrils between Collagen Type II and Collagen Type IX.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human COL9A1.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human COL9A1.
