84-4381-56　［取扱停止］COL15A1 (Collagen alpha-1(XV) Chain) 50ul　360007

特徴

• Collagen Type XV (COL15 gene product) and XVIII (COL18 gene product) form the new subgroup MULTIPLEXIN, within the diverse family of collagens, which contains nineteen distinct types of collagens found in vertebrates.
• Both Type XV and XVIII collagens are characterized by extensive interruptions in their collagenous sequences.
• Members of the MULTIPLEXIN subgroup contain polypeptides with multiple triple-helical domains separated and flanked by non-triple-helical regions.
• Type XV is predominantly expressed in internal organs such as adrenal gland, kidney and pancreas.
• Type XVIII encodes two different a1 chains, which have different signal peptides and variant N-terminal non-collagenous NC1 domains of 495 and 303aa..
• The long variant NC1-434 Type XVIII mRNAs are predominantly expressed in liver, while the variant NC1-303 mRNAs are predominantly expressed in heart, kidney, placenta, prostate, ovary, skeletal muscle and small intestine.
• Endostatin is a fragment of the C-terminal domain NC1 of Collagen Type XV and XVIII that inhibits angiogenesis and tumor growth.
• Unlike endostatin XVIII, endostatin XV does not bind zinc or heparin, however both endostatins can inhibit chorioallantoic membrane angiogenesis induced by basic FGF or VEGF.
• Collagen Type XV and XVIII are also widely present in basement membrane zones, suggesting their roles in basement membrane-stromal interactions and involvement with angiogenic and pathological processes.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.