CDY is a gene family expressed exclusively in the testis that localizes to a region of the Y chromosome frequently deleted in infertile males.
CDY proteins contain two functional domains, an N-terminal chromodomain, possibly functioning in heterochromatin interactions, and a C-terminal domain, which resembles enoyl-CoA-isomerase, a protein involved in fatty acid oxidation.
Furthermore, CDY proteins act as histone acetyltransferases with strong preference for Histone H4, a process required for the histone to proamine transition in spermatogenesis, consistent with the association with male infertility.
Chromodomain Y-like protein 2 (CDYL2) is a related nuclear protein that is ubiquitously expressed with moderate levels in most tissues.
The gene encoding CDYL2 is located on chromosome 16.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human CDYL2.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human CDYL2.
