RP105 is a mouse B-cell surface molecule that transmits a growth-promoting signal and is implicated in the life/death decision of B cells.
RP105 has tandem repeats of a leucine-rich motif in its extracellular domain that are presumed to be involved in protein-protein interactions.
The amino acid sequence of human RP105 is highly homologous to that of mouse RP105; human RP105 shares 74% identity with the mouse protein, as well as the leucine-rich motif.
Surface expression of RP105 is enhanced in the presence of MD1, although this expression is restricted to CD19-positive B cells.
RP105 demonstrates predominant expression on mature B cells in mantle zones; very little expression is observed in germinal centers.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes human CD180. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to residues in human CD180.
