C-C or beta chemokine family members are characterized by a pair of adjacent cysteine residues and serve as potent chemoattractants and activators of monocytes and T cells.
C-C chemokine receptor family members include CKR-1, CKR-2A, CKR-2B, CKR-3, CKR-4, CKR-5, CKR-6, CKR-7 and the Duffy blood group antigen.
Each of these receptors are G protein- coupled, seven pass transmembrane domain proteins whose major physiological role is to function in the chemotaxis of T cells and phagocytic cells to areas of inflammation.
However, this receptor family has also been shown to facilitate viral infection.
CKR-4 (C-C chemokine receptor type 4), also known as CCR4 or CMKBR4, is a 360aa multi-pass membrane protein that localizes to the cell membrane and belongs to the C-C chemokine receptor family.
Expressed at high levels in peripheral blood leukocytes and thymus tissue, CKR-4 functions as a high affinity receptor for C-C type chemokines and is thought to be involved in hippocampal- neuron survival.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3 0.05% sodium azide.
Specificity：Recognizes human CCR4. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to human CCR4.
