This gene is one of several cytokine genes clustered on the q-arm of chromosome 17.
Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes.
The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide.
This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues.
This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils.
It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis.
It binds to chemokine receptors CCR2 and CCR4.
Applications:Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1;50-1:200Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human CCL2.
Isotype：IgG
Calc Applications Abbrev：IF IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human CCL2.
