CatSper is an ion transport protein located on the surface of sperm cells.
CatSper (for cation channel of sperm) is vital to cAMP-mediated calcium influx in sperm, sperm motility and fertilization.
The gene that encodes CatSper maps to human chromosome 11q12.1.
The 686aa protein is a single, six-transmembrane-spanning protein of the voltage- dependent Ca2+ channel four-repeat structure and is expressed exclusively in the testis.
In CatSper -/- sperm, neither cAMP nor cGMP elicit a significant Ca2+ influx in both mutant and wild-type sperm.
CatSper is localized to the sperm flagellum and CatSper -/- mice show sluggish and less directed movements.
CatSper is required to penetrate the egg, but is not required for egg activation.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.
Specificity：Recognizes human CATSPER1. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to residues in human CATSPER1.
