84-4379-89　［取扱停止］CALCA (Calcitonin Gene-Related Peptide 1, Alpha-type CGRP, Calcitonin Gene-Related Peptide I, CGRP-I, CALC, CALC1) 100ul　359909

特徴

• Calcitonin is a 32aa polypeptide hormone that preserves skeletal integrity and reduces blood calcium levels by decreasing osteoclast activity in bones, calcium and phosphate reabsorption by kidney tubules and calcium absorption by the intestines.
• The secretion of Calcitonin from the thyroid is regulated in part by estrogen, which increases Calcitonin mRNA levels.
• The Calcitonin gene, CALCA, undergoes tissue-specific RNA alternative splicing, resulting in the production of different mRNA transcripts.
• One transcript encodes procalcitonin as well as both calcium- lowering processed active polypeptides, Calcitonin and katacalcin.
• An alternative transcript of CALCA encodes the precursor for the neuropeptide referred to as Calcitonin gene-related peptide 1, also designated CGRP1 or a-CGRP.
• CGRP is a widely distributed vasodilatory peptide.
• Calcitonin and katacalcin are produced primarily in the thyroid, while CGRP is produced in neuronal cells.
• A second CGRP related gene, CALCB, thought to be derived from an gene duplication event, has been identified in mouse, rat and human.
• Unlike CALCA, CALCB is not subject to alternative splicing and encodes a single transcript designated CGRP2 or beta-CGRP.
• Mature CGRP1 and CGRP2 share significant sequence identity at the protein level differing by only 1-3 aa residues, depending on the species.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.