84-4379-36　［取扱停止］BHLHB2 (Class E Basic Helix-loop-helix Protein 40, bHLHe40, Class B Basic Helix-loop-helix Protein 2, bHLHb2, Differentially expressed in chondrocytes Protein 1, DEC1, Enhancer-of-split and hairy-Related Protein 2, SHARP-2) 50ul　359882

特徴

• Human DEC1, also known as SHARP2, is a 412aa, basic helix-loop-helix (bHLH) containing protein that is involved in the control of proliferation and/or differentiation of several cell types including nerve cells, fibroblasts and chondrocytes.
• The bHLH region of DEC1 is structurally similar to the bHLH regions of the mammalian HES family, Drosophila hairy and Drosophila Enhancer of split m7.
• DEC1 is a novel direct target for cAMP in a wide range of cells, and is involved in the control of gene expression in cAMP-activated cells.
• Brief light impulses induce the expression of DEC1 in a phase-dependent manner.
• DEC1 is highly expressed in cartilage, intestine, lung and spleen.
• DEC1 and DEC2 play a role in regulating the mammalian molecular clock by suppressing the transcription of specific clock genes.
• Both DEC1 and DEC2 are detected in the suprachiasmic nucleus in a circadian fashion.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.