Atg2B (ATG2 autophagy related 2 homolog B) is a 2078aa protein belonging to the ATG2 family.
Encoded by a gene that maps to human chromosome 14q32.2, Atg2B is conserved in chimpanzee, canine, bovine, mouse, chicken, zebrafish, fruit fly, mosquito and Caenorhabditis elegans.
16 known human ATG genes exist, of which four (Atg2B, Atg5, Atg9B and Atg12) possess mononucleotide repeats with seven or more nucleotides.
Atg2B frameshift mutations may contribute to development of cancer via disruption of autophagy.
Atg2B associates with Atg2A, which is also linked to frameshift mutations associated with gastric and colorectal carcinomas with high microsatellite instability, indicating that these two related proteins functionally interact.
WIPI-4, which is phylogenetically related to both Atg18p and Atg21p, associates with Atg2B and reciprocally binds Atg2A.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:100Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes human ATG2B. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to residues in human ATG2B.
