ARHGEF9 (Rho guanine nucleotide exchange factor 9), also known as PEM-2 homolog or Collybistin, is a 516aa cytoplasmic protein.
ARHGEF9 acts as a guanine nucleotide exchange factor for Cdc42 and promotes formation of Gephyrin clusters by directly interacting with Gephyrin.
ARHGEF9 contains one DH (DBL-homology) domain, one PH domain and one SH3 domain.
Defects in the gene encoding ARHGEF9 are a believed to be a cause for startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy.
This disease is a heterogenous neurological disorder characterized by muscular rigidity, particularly in the neonatal period, and a startle response to auditory or tactile stimuli.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes human ARHGEF9. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human ARHGEF9.
