GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins.
ARHGAP20 (Rho GTPase activating protein 20), also known as KIAA1391, is a 1191aa protein that contains one PH domain, one Ras-associating domain and one Rho-GAP domain.
Expressed primarily in brain, but also present in lymph nodes and fetal liver, ARHGAP20 functions as a GTPase-activating protein for Rho-type GTPases, effectively converting Rho-type GTPases to an inactive, GDP-bound state.
ARHGAP20 exists as multiple isoforms that are produced via alternative splicing.
Chromosomal aberrations involving the ARHGAP20 gene are thought to be a cause of B-cell chronic lymphocytic leukemia (B-CLL).
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.
Specificity：Recognizes human ARHGAP20. Species Crossreactivity: rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Rt
Immunogen：Synthetic peptide corresponding to residues in human ARHGAP20.
