Anthrax toxin receptor 2 (ATR2), also designated capillary morphogenesis gene 2 (CMG2), is a cellular receptor for anthrax toxin.
ATR2/CMG2 is a type 1 membrane protein that includes an extracellular von Willebrand factor A (VWA) domain with a metal ion-dependent adhesion site (MIDAS) motif.
ATR2/CMG2 binds to protective antigen (PA) which is one of the three monomeric proteins which are released as anthrax toxin from Bacillus anthracis.
Once bound, PA facilitates the delivery of the other two proteins, edema factor (EF) and lethal factor (LF), into the cytosol.
Mutations in the gene ATR2/CMG2 result in inhibition of binding by the vWA domain, associated with infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF).
ISH and JHF are rare stiff-skin syndromes characterized by hyaline desposition in various organs, especially the skin and gingiva.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human ANTXR2.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to human ANTXR2.
