Angiogenesis is defined as the process of neovascularization and formation of new blood vessels from the established micro-circulation.
Angiogenin (ANG or ANG I) is a non-glycosylated polypeptide, 123aa in length, whose function is central to this process.
ANG I shows a high degree of homology with known ribonucleases such as pancreatic ribonuclease A, and the capacity of ANG I to induce blood vessel growth is critically dependent on its ribonucleolytic activity.
ANG I is thought to be involved in the development of solid tumors, and ANG I antagonists are capable of inhibiting tumor growth.
By a poorly understood mechanism, ANG I is endocytosed by subconfluent endothelial cells and translocated to the nucleus where it accumulates in the nucleolus.
The ANG I receptor has not yet been identified.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.
Specificity：Recognizes human ANG. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to human ANG.
