84-4377-59　［取扱停止］AMHR2 (Anti-Muellerian Hormone type-2 Receptor, Anti-Muellerian Hormone type II Receptor, AMH type II Receptor, MIS type II Receptor, MISRII, MRII, AMHR, MISR2) 100ul　359779

特徴

• MISR II (anti-Muellerian hormone type-2 receptor, MIS type II receptor) is a 573aa protein encoded by the human gene AMHR2.
• MISR II belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily and contains one protein kinase domain.
• Upon ligand binding, MISR II forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.
• These type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate Smad transcriptional regulators.
• MISR II also acts as a receptor for anti-Muellerian hormone.
• Defects in AMHR2 are the cause of persistent Muellerian duct syndrome type 2 (PMDS-2).
• PMDS-2 is a form of male pseudo-hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.