Phosphatidic acid and lysophosphatidic acid are phospholipids involved in lipid biosynthesis and signal transduction.
LPAAT-Beta (lysophosphatidic acid acyltransferase, beta), also known as AGPAT2, BSCL, BSCL1, LPAAB or 1-AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2), is a multi-pass membrane protein localized to the endoplasmic reticulum that catalyzes the synthesis of phosphatidic acid from lysophosphatidic acid.
Predominantly expressed in heart and liver, LPAAT-Beta belongs to the LPAAT family of proteins that have a well-known role in lipid biosynthesis.
In addition, LPAAT family members may also play a role in tumor progression.
Mutations in the gene encoding LPAAT-Beta can result in the autosomal recessive disorder CGL1 (congenital generalized lipodystrophy type 1).
CGL1, also known as Berardinelli-Seip congenital lipodystrophy type 1 (BSCL1), is a disorder characterized by insulin resistance, early onset of diabetes, hepatic steatosis, scarcity of adipose tissue and hypertriglyceridemia.
Applications:Suitable for use in Immunofluorescece, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:50-1:200Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide, 50% glycerol.
Specificity：Recognizes human AGPAT2.
Isotype：IgG
Calc Applications Abbrev：IF IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to human AGPAT2.
