84-4376-97　［取扱停止］ADAMTS7 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 7, EC:3.4.24.-, ADAM-TS 7, ADAM-TS7, ADAMTS-7, COMPase) 50ul　359747

特徴

• ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer.
• ADAMTS protein family members contain an N-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a C-terminus that contains a varying number of thrombospondin type-1 (TSP-1) motifs.
• ADAMTS genes are primarily expressed in fetal tissues, including lung, kidney and liver.
• ADAMTS-7 (ADAM metallopeptidase with thrombospondin type 1 motif, 7), also known as COMPase, is a 1686aa protein that exists as two alternatively spliced isoforms.
• Encoded by a gene that maps to human chromosome 15q25.1, ADAMTS-7 contains eight TSP-1 motifs and binds one zinc ion per subunit.
• ADAMTS-7 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
• ADAMTS-7 is also located in meniscus, bone, tendon, cartilage, synovium, fat and ligaments, and is up-regulated in articular cartilage and synovium in arthritis patients.
• ADAMTS-7 functions as a metalloprotease and may play a role in the degradation of COMP.
• ADAMTS-7 is pH dependent, with optimum pH between 7.5 and 9.5.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.