84-4376-87　［取扱停止］ADAM28 (Disintegrin and Metalloproteinase Domain-containing Protein 28, ADAM 28, Epididymal Metalloproteinase-like, Disintegrin-like and Cysteine-rich Protein II, eMDC II, Metalloproteinase-like, Disintegrin-like, and Cysteine-rich Protein L, MDC-L, ADAM) 50ul　359742

特徴

• The ADAM (a disintegrin and metalloprotease) protein family, which includes over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases, plays a role in cell-cell and cell-matrix interface related processes, including fertilization, muscle fusion, secretion of TNFa (tumor necrosis factor a), and modulation of the neurogenic function of Notch and Delta.
• The ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (integrin ligand), a cysteine-rich region, an epidermal growth factorlike domain, a transmembrane domain and a cytoplasmic tail.
• ADAMs are expressed in a wide range of mammalian tissues and several are abundantly expressed in the male reproductive tract.
• ADAM28, also designated MDC-L,is more closely related to snake venom metalloproteases (SVMPs) than to other ADAM family members.
• ADAM28 displays a high level of expression in lymphocytes and epididymis, and functions mainly on the cell surface, where it mediates cell adhesion through its binding to integrin a4B1.
• The gene encoding human ADAM28 maps to chromosome 8p21.2.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.