84-4376-79　［取扱停止］ACTR1A (Alpha-Centractin, Centractin, ARP1, Actin-RPV, Centrosome-Associated Actin Homolog, CTRN1) 50ul　359738

特徴

• The dynactin complex is a macromolecular complex that consists of 10-11 distinct subunits.
• This complex is critical for the function of dynein, a molecular motor protein.
• Dynactin plays a role in ER to Golgi transport, spindle formation, chromosome movement, axon guidance, nuclear positioning and the centripetal movement of lysosomes and endosomes.
• Centractin is a subunit of the dynactin complex that exists in multiple isoforms.
• The alpha isoform, also known as actin-related protein 1 homolog A (Arp1) and previously referred to as centractin, is the most abundant isoform in the dynactin complex.
• The beta isoform, also known as actin-related protein 1 homolog B, shares 90% identity with the alpha isoform.
• The two isoforms, alpha and beta, are expressed at a ratio of 15:1 respectively.
• The backbone filament structure of the dynactin complex (important for the arrangement of other complex proteins) is composed of 9-11 subunits of alpha/beta-centractin.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.