84-4376-57　［取扱停止］ABHD13 (Alpha/beta Hydrolase Domain- Containing Protein 13, Abhydrolase Domain-Containing Protein 13, C13orf6) 50ul　359727

特徴

• The a/b hydrolase superfamily comprise diverse members that are involved in important biochemical processes and related to various diseases.
• They have unrelated sequences, various substrates, and different kinds of catalytic activities, yet they share the same canonical a/bhydrolase fold, which consists of an eightstranded parallel a/b structure.
• They are also characterized by a catalytic triad composed of a histidine, an acid and a nucleophile.
• Members of this superfamily are often drug targets for treating diseases, such as diabetes, Alzheimer’s disease, obesity and blood clotting disorders.
• The Ab hydrolase domain containing (ABHD) gene subfamily is comprised of 15 mostly uncharacterized members.
• Most of which utilize a serine nucleophile to form the G-X-S-X-G nucleophile elbow.
• ABHD1 plays a role in metabolizing smoking xenobiotics.
• ABHD2 participates in the development of atherosclerosis.
• ABHD4 is involved in an alternative synthesis pathway of NAE.
• Mutations in ABHD5 contribute to Chanarin-Dorfman syndrome.
• ABDH6 may play a role in nervous system metabolism and signaling.
• ABHD13 is a 337aa single-pass membrane protein that belongs to the ABHD family.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.