Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene.
It is mapped to 22q12.1-q13.2.
This gene belongs to the tissue inhibitor of metalloproteinases gene family.
The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of theextracellular matrix (ECM).
Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM.
Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 0.1-0.5ug/mlELISA: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Reconstitute with sterile ddH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder in 5mg BSA, 0.9mg sodium chloride, 0.2mg Na2HPO4, 0.05mg sodium azide. Reconstitute with 200ul sterile dH2O to ~0.5mg/ml.
Specificity：Recognizes human TIMP3. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to C-24-P211 of human TIMP3 expressed in E. coli. Species sequence homology: mouse (97.9%) and rat (97.3%).
