84-4376-05　TGFBR1 (Transforming Growth Factor, Beta Receptor 1, AAT5, ALK 5, ALK5, ALK-5, MSSE, SKR 4, SKR4, TbetaR I, TbetaR-I, TGF B Receptor I, TGF beta Receptor I, TGF beta Receptor Type 1, TGF beta Receptor Type I, TGF beta Type I Receptor, TGF-beta Receptor Type I, TGF-beta Receptor Type-1, TGF-beta Type I Receptor, TGFBR 1, TGFBR1 Protein, TGFR 1, TGFR1, TGFR-1) 100ug　353308

特徴

• Transforming growth factor, beta receptor I, is a TGF beta receptor.
• TGFBR1 is its human gene.
• The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm.
• Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
• TGFB1 regulates cell cycle progression by a unique signaling mechanism that involves its binding to TGFBR2 and activation of TGFBR1.
• Both are transmembrane serine/threonine receptor kinases.
• The TGFBR1 receptor may be inactivated in many of the cases of human tumor cells refractory to TGFB-mediated cell cycle arrest.
• Vellucci and Reiss (1997) reported that the TGFBR1 gene is ~31kb long and contains 9 exons.
• The organization of the segment of the gene that encodes the C- terminal portion of the serine/threonine kinase domain appears to be highly conserved among members of the gene family.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.