84-4375-58　Factor B (Complement Factor B, AHUS4, B Factor Properdin, BF, BFD, C3 Proaccelerator, C3 Proactivator, CFAB, CFB, Complement Factor B, FB, FBI12, GBG, Glycine Rich beta Glycoprotein, H2 Bf, H2BF, PBF2, Properdin Factor B) 100ug　353256

特徴

• Complement factor B is a protein that in humans is encoded by the CFB gene.
• This gene encodes complement factor B, a component of the alternative pathway of complement activation.
• Factor B circulates in the blood as a single chain polypeptide.
• Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb.
• The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase.
• Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation.
• This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.
• This cluster includes several genes involved in regulation of the immune reaction.
• Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration.
• The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlImmunohistochemistry (paraffin): 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.