84-4375-39　CD2 (T-cell Surface Antigen CD2, CD2 Antigen, CD2 Molecule, LFA2, LFA-2, Rosette Receptor, SRBC, T Cell Surface Antigen CD2, T11, Tcell Surface Antigen CD2, T-cell Surface Antigen CD2, T-cell Surface Antigen T11) 100ug　353237

特徴

• CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells.
• It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor.
• Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.
• CD2 is one of the earliest T-cell markers, being present on more than 95% of thymocytes.
• Due to its structural characteristics, CD2 is a member of the immunoglobulin superfamily; it possesses two immunoglobulin-like domains in its extracellular portion.
• The localization of CD2 to 1p13 is established by in situ hybridization.
• CD2 interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells.
• With the use of transgenic mice, such an LCR is identified within the 3-prime flanking region of the human CD2 gene.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlImmunohistochemistry (paraffin): 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.