84-4375-26　Apolipoprotein A I (Apo AI, APOA 1, ApoA I, ApoA-I, Apo-AI, Apolipoprotein A1, Apolipoprotein AI, Apolipoprotein A-I, Apolipoprotein A-I(1-242), ProapoA-I, Proapolipoprotein A-I, Truncated Apolipoprotein A-I) 100ug　353224

特徴

• Apolipoprotein A-1, also known as APOA1, is a human protein with a specific role in lipid metabolism.
• It binds to lipopolysaccharide or endotoxin, and has a major role in the anti- endotoxin function of HDL.
• The gene is mapped to 11q23.
• And it is a single polypeptide chain with 243aa residues of known primary aa sequence.
• The ApoA-I protein promotes cholesterol efflux from tissues to the liver for excretion.
• It is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters.
• ApoA-I is also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect.
• Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.
• Additionally, ApoA-I overexpression promotes macrophage-specific reverse cholesterol transport.
• Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 0.1-0.5ug/mlImmunohistochemistry (paraffin): 0.1-0.5ug/mlWestern Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.