84-4375-02　SPTLC1 (Serine Palmitoyltransferase 1, Serine Palmitoyltransferase, Long Chain Base Subunit 1, HSAN1, HSN1, LCB 1, LCB1, Serine-palmitoyl-CoA Transferase 1, SPT1, SPT-1, SPTC1, SPTLC 1, SPTLC-1) 100ug　353048

特徴

• SPTLC1(Serine palmitoyltransferase, long chain base subunit 1), also known as SPT1, LCB1, is a protein which in humans is encoded by the SPTLC1 gene.
• Dawkins et al.
• (2001) noted that the SPTLC1 gene maps to chromosome 9q22.1-q22.3.
• Serine palmitoyltransferase, which consists of two different subunits, is the initial enzyme in sphingolipid biosynthesis.
• It converts L-serine and palmitoyl CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor.
• The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase.
• Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1.
• Alternatively spliced variants encoding different isoforms have been identified.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlImmunohistochemistry (paraffin): 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.