84-4374-94　Scn1a (Sodium Channel Protein type 1 Subunit alpha, Sodium Voltage-gated Channel alpha Subunit 1, EIEE6, FEB3A, FHM3, GEFS+2, GEFSP2, NAC1, SCN1, Nav 1.1, SCN1A, SMEI) 100ug　353031

特徴

• Nav1.1, also known as the sodium channel, voltage-gated, type I, alpha subunit (SCN1A), is a protein which in humans is encoded by the SCN1A gene.
• Voltage-dependent sodium channels are heteromeric complexes that regulate sodium exchange between intracellular and extracellular spaces and are essential for the generation and propagation of action potentials in muscle cells and neurons.
• Each sodium channel is composed of a large pore-forming, glycosylated alpha subunit and two smaller beta subunits.
• This gene encodes a sodium channel alpha subunit, which has four homologous domains, each of which contains six transmembrane regions.
• Allelic variants of this gene are associated with generalized epilepsy with febrile seizures and epileptic encephalopathy.
• Alternative splicing results in multiple transcript variants.
• The RefSeq Project has decided to create four representative RefSeq records.
• Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.