84-4374-45　［取扱停止］CNP (2',3'-cyclic-nucleotide 3'-phosphodiesterase, CNPase, CNP1) 100ul　352678

特徴

• CNP (2’, 3’-Cyclic Nucleotide 3’-Phosophodiesterase) has two isoforms, CNPase1 (46kD) and CNPase2 (48kD), which are encoded separately by different promoters of the same gene.
• CNP is found in high levels in the brain and peripheral nerve, almost exclusively in oligodendrocytes and Schwann cells.
• CNP is the third most abundant protein found in the central nervous system myelin.
• It is found early in oligodendrocyte development and continues to be found in adult animals.
• It may play a role in RNA metabolism in the myelinating cell.
• CNP antibody can be used as a marker for oligodendrocyte and Schwann cells.
• CNP levels have been found to greatly reduced in various diseases, neurological mutant and in experimental conditions in which myelin is reduced.
• Additionally, reduced CNP brain levels have been reported in Down syndrome and Alzheimer’s disease. 
• Applications:Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry ,Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Immunofluorescence: 1:1000-5000Western Blot: 1:1000-2000Immunohistochemistry: 1:1000-5000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.