84-4374-03　UHRF1BP1 (ICBP90, Ubiquitin-like Containing PHD and RING Finger Domains 1-binding Protein 1, C6orf107, UHRF1-Binding Protein 1, ICBP90-Binding Protein 1) 100ug　352627

特徴

• The Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1 (UHRF1BP1), also known as ICBP90, is a transcription and cell cycle regulator.
• It specifically binds to the histone H3 N-terminal tail when methylated on K9 by two functional domains, a PHD finger that defines the binding specificity and an SRA (SET- and RING-associated) domain that promotes binding activity.
• UHRF1BP1 is required for proper heterochromatin formation in mammalian cells.
• Furthermore, UHRF1BP1 is thought to be a pivotal target for the ERK1/2 signaling pathway to control the proliferation of Jurkat T cells.
• Applications:Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunofluorescence: 20ug/mlWestern Blot: 1-2ug/mlImmunohistochemistry: 2.5ug/ml Optimal dilutions to be determined by the researcher.
• Positive Control:Mouse Kidney Tissue Lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.