TRIM24 (TIF1), a member of the tripartite motif (TRIM) family, plays a role in the regulation of cell proliferation and apoptosis.
TRIM24 localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors.
The TRIM motif includes three zinc- binding domains (RING, B-box type 1 and B-box type 2) and a coiled-coil region.
TIF1 mediates transcriptional events by interactions with the AF2 region of several nuclear receptors, such as the estrogen, retinoic acid and vitamin D3 receptors.
Defects in TRIM24 are a cause of thyroid papillary carcinoma (TPC).
Applications:Suitable for use in Immunofluorescence, Western Blot and Immunocytochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1-2ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:EL4 Cell Lysate
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human TRIM24. Species Crossreactivity: rat
Isotype：IgG
Calc Applications Abbrev：IC IF WB
Calc Crossreactivity：Hu Rt
Immunogen：Peptide corresponding to 19aa from human TRIM24.
