84-4373-32　SREBF1 (SREBP1, SREBP-1c, BHLHD1, Sterol Regulatory Element-Binding Protein 1, Class D Basic Helix-Loop-Helix Protein 1, SREBP-1) 100ug　352554

特徴

• The sterol regulatory element binding transcription factor 1 (SREBF1) is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis (1).
• The related protein SREBF2 also binds SRE1 and activates transcription in an additive fashion to SREBF1 (2).
• SREBF1 is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum.
• Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1 (3).
• The SREBF1 proteins are important in the regulation of genes involved in lipid metabolism, while SREBF2 has been more closely associated with cholesterol synthesis and accumulation (4).
• Applications:Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunofluorescence: 20ug/mlWestern Blot: 1-2ug/mlImmunohistochemistry (paraffin): 5ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Daudi Cell Lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.