Alpha-Synuclein (SNCA) is a hallmark of Alzheimer’s disease (1,2).
It is a cytoplasmic protein that is predominantly expressed in the central nervous system (2).
SNCA reduces neuronal responsiveness to various apoptotic stimuli, leading to the decreased caspase-3 activation.
SNCA may be involved in the regulation of dopamine release and transport and induces fibrillization of microtubule-associated protein tau (3).
Defects in SNCA are associated with familial Parkinson’s disease (4,5).
Applications:Suitable for use in Immunofluorescence, ELISA, Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 20ug/mlWestern Blot: 1-2ug/mlImmunohistochemistry (paraffin): 5ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:Mouse Cerebellum Tissue Lysate
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human SNCA. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E IF IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Peptide corresponding to 19aa near the C-terminal of human SNCA.
