84-4373-15 SMURF1, NT (SMAD specific E3 ubiquitin protein ligase 1, SMAD ubiquitination regulatory factor 1, E3 ubiquitin-protein ligase SMURF1) 100ug 352537
特徴
- SMURF1 (SMAD ubiquitin regulatory factor 1) is a negative regulator of TGF-beta signaling (1).
- SMURF1 and SMURF2 are members of HECT domain E3 ubiquitin ligase which are involved in the enzymatic reactions of the Ub conjugating pathway (1,2).
- SMURF1 negatively regulates osteoblast activity and response to bone morphogenesis protein (BMP) through controlling MEKK2 degradation (3).
- SMURF1 has recently been shown to play a role in breast cancer cell migration and invasion through the downregulation of RhoA (4)
- Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry.
- Other applications not tested.
- Recommended Dilution:Western Blot: 1-2ug/mlImmunohistochemistry (paraffin): 5ug/mlOptimal dilutions to be determined by the researcher.
- Positive Control:293 Cell Lysate
- Storage and Stability:May be stored at 4°C for short-term only.
- Aliquot to avoid repeated freezing and thawing.
- Store at -20°C.
- Aliquots are stable for 12 months after receipt.
- For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
- Size：100ug
- Host：rabbit
- Source Antibody：human
- Grade：Affinity Purified
- Purity：Purified by immunoaffinity chromatography.
- Form：Supplied as a liquid in PBS, 0.02% sodium azide.
- Specificity：Recognizes human SMURF1 Species Crossreactivity: mouse and rat
- Isotype：IgG
- Calc Applications Abbrev：E IHC WB
- Calc Crossreactivity：Hu Mo Rt
- Immunogen：Peptide corresponding to 16aa near the N-terminal of human SMURF1.
- Shelf Life：6months
- Swiss Prot Number：Q9HCE7
- EU Commodity Code：30021010
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