PTCHD2, also known as DISP3, is the third of three known homologs of the D.
melanogaster protein Dispatched.
It is a multitransmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored secreted proteins.
Like DISP1 and DISP2, DISP3 has been implicated in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis.
It is highly expressed in Purkinje cells, hippocampal neurons, and retinal ganglion cells.
Recently, it has been shown that PTCHD2 localizes within theendoplasmic reticulum and colocalizes with cholesterol, and given that its expression is regulated by thyroid hormone (T3), it has been suggested that DISP3 may be a link between thyroid hormone and cholesterol metabolism.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 5ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:Human Testis Tissue Slide
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human PTCHD2.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to 14aa from human PTCHD2 at C-terminal.
