84-4372-18　PINK1, NT (PTEN-induced Kinase, BRPK, PARK6BRPK) 100ug　352438

特徴

• The PTEN-induced putative kinase 1 (PINK1) is a serine/threonine protein kinase that localizes to mitochondria and is thought to protect cells from stress-induced mitochondrial dysfunction (reviewed in 1).
• PINK1 recruits the E3 ubiquitin ligase Parkin to mitochondria to initiate mitophagy, an autophagic process that clears damaged mitochondria within a cell (2).
• PINK1 is cleaved by the mitochondrial protease PARL (3).
• Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease (4)
• Applications:Suitable for use in ELISA, Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1-2ug/ mlOptimal dilutions to be determined by the researcher.
• Positive Control:A431 Cell LysateMouse Spleen Tissue LysateRat Spleen Tissue Lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.