Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes throughout development (1).
PHC3 (Polyhomeotic-like protein 3), also known as Early development regulatory protein 3, is a 983aa nuclear protein that is a component of the PcG multiprotein PRC1 complex (2).
PRC1 complex acts via chromatin remodeling and modification of histones.
PHC3 contains 1 FCS-type zinc finger and SAM (sterile alpha motif) domain (2-3).
PHC 3 has been regarded as a candidate tumor suppressor of osteosarcoma (4).
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1-2ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:3T3 Cell Lysate
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human PHC3. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Peptide corresponding to 19aa near the N-terminal of human PHC3.
