IL-1RL2 is a member of the interleukin 1 receptor family, but it is incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity.
Together with IL-1RAcP, it can bind members of the IL-36 cytokine family, leading to activation of the NF-kappaB pathway.
IL-1RL2 can also bind to IL-1F10, resulting in a decreased product of Th17 cytokines in response to immunological or LPS challenge, suggesting that one potential role of IL-1RL2 may be to modulate the immune and inflammation response.
Applications:Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunohistochemistry.
Other applications have not been tested.
Recommended Dilutions:Immunofluorescence: 20ug/mlWestern Blot: 1-2ug/mlImmunohistochemistry (Paraffin): 5ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:Human small intestine tissue lysate and human small intestine tissue slide
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by peptide affinity chromatography
Form：Supplied as a liquid in PBS, 0.02% sodium azide
Specificity：Recognizes human IL-1RL2. Species Crossreactivity: mouse and rat. At least three isoforms of IL-1RL2 are known to exist; this antibody will detect all three isoforms. Predicted to not cross-react with IL-1R or IL-1RL1.
Isotype：IgG
Calc Applications Abbrev：E IF IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Peptide corresponding to 16aa near the center of human IL-1RL2. Epitope: aa260-310
