The growth arrest-specific 6 (GAS6) protein is a gamma-carboxyglutamic acid (Gla)-containing protein and a member of a family of plasma vitamin K-dependent proteins.
GAS6 is involved in vascular homeostasis, cell proliferation, apoptosis, leukocyte migration, and platelet aggregation (1,2).
GAS6 is the ligand for the type I transmembrane receptor tyrosine kinase receptors Tyro3, Axl, and Mer (3).
This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker (4).
Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia (2)
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1-2 ug/mlImmunohistochemistry (paraffin): 2.5ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:Mouse Heart Tissue Lysate
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human GAS6. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Peptide corresponding to 19aa from near the N-terminal of human GAS6.
